Lachera, being from Italy, has great insight on travel throughout Italy.
To me, a 90-minute drive in the most favorable conditions is more than I would want to tackle for a day trip. If you live in the area and you're driving your personal car-- that is one thing. Driving a rental car on routes you've never driven before, with traffic signs in a different language is a different animal.
At any rate, on the Innsbruck/Bolzano highway, be advised that the Lueg Bridge on the BRENNER PASS WILL HAVE CONSTRUCTION beginning at the end of March, 2025 so that the aged-out Bridge can be replaced.
The construction is expected to narrow the pass to a single lane for a couple miles, which will cause a bottleneck on the already-busy highway while construction is ongoing.
Taking trains is advised until the construction is completed.