Day trip from rome to florence

Yes it's possible, and train is the best way to do it. You'll want to make sure you have all of your sights/museums booked in advanced so you can minimize your time spent queuing.

You can look up itineraries on youtube or trave blogs but basically you take an early train from Rome and a late train back.

Yes, this is certainly possible. I've done it more than once. Book a fast train, leave early, plan well, and you'll be set.

I have done the opposite several times; both tourist day trips and business trips leaving in early morning and coming back in the evening. The trick is doing it by train, as a one-way travel can be done in 1 hour 40 minutes (sometimes even a bit less), while by car you are more likely to need more than double the time. The open country landscape in low Umbria and near Rome is quite hypnotic from the fast train windows.

What are some of the places to visit/see in Rome and Florence that are paid and require a reservation in advance?

sking10

If you post a new topic-your own thread-you’ll get more advice

Rome-Colosseum, Vatican/Sistine Chapel, Borghese

Florence-Accademia David, Uffizi

All need prebooked timed entries

If you post your own question we can provide links to specific official sites you are interested in

A good guide book will also give you the information
RS Italy is very useful