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Colosseum to the Catacombs

What is the best/easiest way to get from the Colosseum to the Catacombs and then from the Catacombs to Vatican Area?

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The largest selektion of catacombs is out along the Via Appia Antica; is this the area you are asking about? If so you can get there by taking the Metro B at the Colosseum to the Piramide stop and then the city bus (I think it's #118 but check) or the hop on-hop off archeobus from the Colosseum stop (expensive). If you take the city bus remember to validate your ticket, and at some of the catacombs the exit may be far from the entrance.