We will be spending 3 nights in Cinque Terra in early May 2026. We will be arriving by train from Siena and then returning to Rome for the flight back to the US. What is the most convenient town in Cinque Terra in terms of train travel? I know that La Spezia is not technically in Cinque Terra, but are the other towns easy to visit from there?
All of the 5 villages (from East to West: Riomaggiore, Manarola, Corniglia, Vernazza, Monterosso) have a station, although Corniglia is way up the hill from the station and to reach it you need to take the very long series of stairways, or the local minibus. I prefer to stay in those villages, rather than La Spezia, an industrial port city.
...and then returning to Rome for the flight back to the US.
Just curious: you're not planning on traveling to Rome from CT on the same day as your flight, are you?
The RS Village Italy tour stays in Levanto, the next town north of CT. That would probably be more enjoyable than La Spezia.
And I agree with the previous post, you should aim to be in Rome the night before your flight home.
.... and then returning to Rome for the flight back to the US
Hopefully the flight back to the US is the day after the train trip to Rome. Even if that is not the plan, that very well could be the result due to missing the flight if you are planning it as a 'same day' thing.
All 5 towns are on the train line and not that far apart so it really doesn't matter which one you stay in.