srme2000, you say you need to take 4 large suitcases with you, so i will accept that and won't tell you to pack light (although I always do.). I myself do not know of any shipping service that could reliably get your suitcases between airports and into your hands for your flight at Milano's airport. Maybe a courier service if you could afford that. If your kids are teens or young adults who can each handle a bag, then your travel in Italy will be challenging. If your kids are young and cannot each handle a bag, then really, good luck! I hope you will not have other carry-on or tote bags along with the big ones. Not only will you have fast trains from Rome to Venice (which is direct, no train changes) and Venice to Milano (be sure to choose a direct schedule, not all selections are), but you will also have to get to and from airports and train stations. Are you spending nights in each of Rome, Venice and Milano, or is one or more just a transit point? I would suggest taxis, you might need large ones, between airport and hotel/station in Rome and Milano. Give yourselves some extra time when arriving at train stations, as you will have to maneuver there to get to your platform, train, proper car, and getting your baggage into the train. For Venice, I recommend that your family have everything you need packed into one suitcase, so you can leave the other three at the baggage storage at the train station, I assume there is one. It might be a little pricey for a few days, but lugging big suitcases around Venice, including its vaporettos or water taxis, will be really a challenge, maybe impossible if your kids are small. Try to be sure your hotel is very near a vaporetto stop, or an easy walk to the train station. Same recommendation for Milano, unless you are going directly from train arrival to the airport. Having written all this, I realize that we could all give you better guidance if you could be more specific -- just what is your planned itinerary with in Italy, in how many places will you be spending time? how old are your "kids"? just what size are these suitcases -- 22", 24", 26" and will you have any smaller bags as well?