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Car Rental location in Rome/Trastavere (traveling to Le Marche region)

I'll be renting a car on my last day in Rome, to drive from Rome to Ascoli Piceno. We'll be staying in an apartment in Trastavere. What would be the best rental agency & office to pick up a car rental from there?

From Ascoli Piceno we'll be driving to other parts of the Le Marche region, thus requiring a car. However, if there are other suggestions for getting from Rome to Ascoli Piceno and renting a car there (bus? train?) let me know. I don't know if there are good options for that.

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16206 posts

Rent fram an agency near the Tiburtina station. Not near Trastevere but from there it is easier to get on the A24freeway.