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Car rental in Florence

Please help me figure out where to pick up rental car. We will be arriving on train from Venice, then touring Florence for half a day, and then heading to our hotel in San Gimignano. So we want a pick-up place convenient to tourist areas. I keep reading about how difficult driving in Florence is; so, more importantly, we need a location with easy exit from Florence. What would you suggest?
Thanks!

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Try SIXT car rental in Florence. The office is in a business/residential area behind the train station that is away from most of the traffic. It was an easy walk from the train station and easy to get out of the city toward San Gimignano. They gave us great directions and a map. If you are returning the car to Florence, there is a little non-attended gas station a couple of blocks from the rental agency.