Wayne in an earlier post mentioned Bologna and I wanted to second his recommendation.
We spent 2 nights at Albergo delle Drapperie in a great location near the markets in the city center. The hotel staff provided us with excellent restaurant recommendations--our favorite was Cesari.
The city is easily walkable with beautiful covered walkways. Our favorite sites were the Oratorio di Santa Ceclia with it's wonderful 16th-century frescoes; the Museo Civico Archeologico with its Egyptian, Roman, and Etruscan collection; the Basilica di San Petronio with it's huge sundial; and Basilica di San Domenico with an early Michelangelo carved angel.
We flew into Malpensa Airport in Milan and took the train directly to Bologna and arrived in less than 2 hours.
Bologna was also a good location for picking up a rental car to visit Tuscany--we toured the region for 6 days and then dropped the car in Perugia.
We had such a pleasant experience in Bologna on a recent trip, that we wonder why it's not included in Rick's Italy book!?