Best location/hotel for seniors to mostly sit-Florence

Can't help with the tours, but the Hotel California (yes, that's the name) is in a central location. It should not be a long walk to any of the sites from there. Go to Google Maps to see the location in relations to various sites.

Outstanding, thanks!

I haven't had a stroke, but if your husband "can walk for a few hours" before he needs to rest, he's doing better than me! ;-)

Depending on the number of stairs or steepness of incline or how fast the group I'm walking with is going, I could be rest-ready in 10 minutes. This is due to a medication I have to take to lower my heart rate. If it goes too high, I could simply pass out. :-)

If he has issues with stairs, you probably want to be aware that although some hotels, restaurants, museums or other sights have elevators, there may be steps to go up or down to get to them and they may not go all the way to the top floor, leaving more stairs to climb. Likewise, sometimes the toilets are up or down stairs as well. Of course, many of the places you might want to visit will have no elevators at all.

I've never taken a tour in Florence, but it's been my experience that most local tours I've been on elsewhere in Italy move at a relatively slow pace. That's the good news. The bad news is that I've noticed that there are very few, if any, places to sit at popular sights -- even museums where you might want to sit down to spend time taking in an amazing work of art.

Sometimes it's more exhausting to stand and listen to a tour guide than to keep moving at a slow pace. These situations and walking on rough surfaces are the reasons comfortable and supportive walking shoes and supportive compression socks are recommended to help avoid fatigue.

Florence is a wonderful place to visit. I've spent about 4 weeks there over the years. Assuming you're going when the weather is good for sitting outside, it's a great place for doing that. If it's not, there are lots of places where you can sit next to windows and get almost the same view.

If you haven't done much online exploration yet, below is one of many good resources to take a look at. It hits the high points and you can click on them for more information where you'll also be able to click on their websites.

2 days in Florence: the itinerary: https://www.italia.it/en/tuscany/florence/things-to-do/florence-weekend-breaks#

When I tried it, I chose the Uffizi Gallery, clicked on the Website link, then on "Come and visit us" (above the Gli Uffizi banner) and got to a page with many other link options for more information that I think you might find useful -- especially the part on Accessibility. The listing under "Services" (below the Gli Uffizi banner) has other useful information including on the Cafeteria which is a great place to take a break.

I didn't explore any of the other highly recommended sights. It was making me want to get on a plane ASAP.

I don't have personal recommendations, and it sounds that your husband had more mobility than some, but I wonder if searching for accessible hotels will give you an idea of useful hotels or location in the city to consider.
There are also are tour companies for people with disabilities. Review their itineraries for hotel suggestions, sites that may be easier to deal with and an itinerary pace that may work for framing your plans.
I agree that standing and listening may be more difficult than a slow steady saunter. I rarely use guides, but perhaps an occasional private guide can be hired for locations you feel a guide is a must. Consider asking for more of an overview rather than an in depth explanation tour, or stating husband will direct how much detail he wants when he wants it.
Also, not knowing the physical results of his stroke, would a walker (wish a seat) or mobility scooter be of any value?

Wonderful insight and feedback, many thanks.

We just stayed at Albergo Firenze (two weeks ago), reasonable price. Has elevator and I felt like it was an easy walk to many attractions - duomo is super close, accademia and and ufiizi were like 15 minutes each but in opposite directions. piazza republicca also very close, so lots of shopping. We stopped back to hotel multiple times and found it very convenient. Do know, ponte vechio was a tad further away and piazzele michaelangelo might be out of reach for your husband on foot. The staff was very helpful and friendly.

We also spent time in orvieto and venice at similar priced hotels. They had significantly better breakfasts, but this was enough of an offering to get you fed and out the door. also, i found the bathroom at albergo firenze a tough lay out...getting into tub might be difficult for someone with mobility issues. however, friends were in different room with shower only so that might be better option for safety. Room was tiny (italy!) and dark (weird lighting) but I would probably stay again. if I could...

We did Brunelleschi pass at duomo, and skip line at Uffizi and Accademia, Medici Chapels and Palace as well as wandered RS walk...

Hotel Cavour (higher price )has a nice rooftop terrace (terraza divine) for views (!) -- reservation only (email them) and one drink minimum. its close walk from albergo firenze and elevator gets you to the view. Nice place to sit for an hour.

Please excuse ALL spelling errors

This is very helpful, thanks for taking the time to respond.