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Best Connections, Prague to Milan/Rome or vice versa

We're planning a couple weeks in Italy and Prague. Does anyone have any suggestions of (1) order, and (2) best method of connection? We're simply roughing in our plans now.

Never been to Prague. We've been to Italy and are comfortable getting around there. We'd like to visit Lake Como north (in or out of Milan) and Amalfi (in or out of Rome or Naples) south. Not interested in spending time in Milan, Rome or Naples on this trip, except as an exit or entry point.

I hope this will take place either Spring or early Fall 2010. Thanks in advance for your advice.

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