Ok, after countless hours planning and reading and planning some more, I think I have a doable and leisurely schedule set-up for Rome.
Tuesday - Arrive in the AM, get situated in the apartment, and depending on jet lag:
a) Walk around, see the Castel Sant' Angelo, , St Peter's Square (Basilica maybe), do stroll in evening (Navona to Spagna)
b)If feel up to it Vatican Museum/Sistine Chapel (12-1) ( best time to be there according to Ron in Rome)
Wednesday - Campo dei Fiori and San Giovanni in Laterano and Roman Colosseum, Forum, Roman Pantheon, Piazza del Campidoglio and Capitoline Museum (Evening is free for a nice sit down meal)
Thursday - Ostia Antica and Mediterranean Sea (afternoon - Galleria Borghese Museum (need reservations)
Friday -Florence (Early morning leave, late return) Need reservations for Accademia Galleries and Uffi Gallery)
Saturday - May 1st - (Holiday) walk around Rome (Piazze - Piazza di Spagna (Spanish Steps), Piazza Navona (Fountain of Four Rivers), Piazza del Popolo and Piazza Venezia and the Trevi Fountain - Possibilities -Church hopping/Appian Way
Sunday -Portese Flea Market (morning) 1st chance to do whatever we missed or want to see twice
Monday - – Vatican Museums and Sistine Chapel (Trastevere) or Pompeii (depends on what we did Tuesday)
Tuesday - Tivoli (Villa Este) half day or Pompeii (Cameos) full day or Vatican Museums(again depends on what has already been done)
Wednesday – Papal Audience - 2nd Chance to do whatever we missed or want to see twice
Thursday – 3rd Chance to do whatever we missed (absolutely nothing planned)
Friday - leave AM for 11:00 flight
Any suggestions and critiques are welcome. I think we have planned a leisurely time in Rome (except for the Pompeii and Florence trips). Thanks, as always for the tips and suggestions.