We landed on Sardinia 2 nights ago, in Cagliari. We’re going back to that city in a week and a half, after driving to other parts of Sardinia. We’re currently spending our second of three nights in Sant’ Antioco, a small city on a small island with the same name, connected to the main island of Sardinia by a causeway. They just had a big annual festival today, but we’ve heard only two other English speakers, and they clearly weren’t native speakers, from their accents. There was also a car parked along a street tonight with UK plates. Maybe they have a second home here, or perhaps they just drove a long way from home. I get the impression there are a few Brits who come to Sardinia, and apparently few people who speak German, but relatively few tourists. Maybe the tourists on Sardinia are other Italians.
Very few residents here appear to speak or understand much English. That includes people who run restaurants, shops, market stands, and car rental desks. If you want some place that feels off the beaten tourist track, especially for Americans, Sardinia would seem to be a good candidate. Well, in April for sure, but in August, I can’t personally guarantee.
We were in Sicily one December, almost empty, and by the Amalfi Coast on the same trip, with lots more people. Again, I can’t say what you’d find in August, but I would venture Sicily would be less crazy packed than mainland Italy. Sardinia likely even less busy, however.
You might also consider Greece, either on the Mani Peninsula at the southwestern end of the Peloponnese, or on Crete. When we vacationed on Crete in September (I know, not August), there were lots of people at the beach town of Agios Nikolaos, but almost nobody else at the black sand beaches of Kato Zakros. There were some people, mostly Germans, on vacation at Pitsidia (just inland from the beach), but not a huge, or even large amount.