Almalfi Coast to Puglia

Hi and welcome to the forum!

According to this previous thread on a similar subject, it's not advised to try and cover both regions in a week. That said, more information would also be helpful such as how many nights on the ground you'd be in Italy, what month/year, where you're looking at flying in/out, your interests (why you are choosing these particular 2 locations), number of travelers and approx. ages, how you plan to get to/around both regions, and anything else that would help people provide useful guidance. Help us out here? :O)

https://community.ricksteves.com/travel-forum/italy/i-m-on-the-fence-days-to-allocate-to-amalfi-coast-puglia

I've not yet been to Puglia (although read plenty about it) but have been to Sorrentine/Amalfi coast region. Trying to cover ground there on tight timelines can be an exercise in frustration. It's not as wearing if you're not trying to get from most A's to B's in a hurry.

I think 1 week could be AMAZING for ONE of those destinations, but I feel like you might be shortchanging both and wasting a day traveling between the two on a very short trip.

One week each? Yes.
For both it would be challenging, especially without a car for Puglia.