I'll be in Rome in a month for a week, and really look forward to it. But, Rome has huge religious elements to it, and I'm not a big fan of religion in general. So I'm not looking for any kind of spiritual experience in Rome - but I do like history, architecture, art, and pizza! So I don't want to a heavy dose of religious stuff - I actually have a pretty irreverent attitude about it, but I can appreciate the feat of painting the ceiling of the Sistine Chapel.
I have some ideas - focusing on imperial Rome, tours that emphasize architecture, and hanging out around places where modern Romans do, but I'm looking for other takes on ways to see Rome from a more pragmatic perspective. Are there places to definitely go to - or avoid - given by goals and interests?