Thanks for the replies. We land in Venice on Sept 15 and will fly home on Sept 30. We will travel by car on the entire trip except for Cinque Terre. We will drive from Venice to Sirmione to Parma (via Modena). Then to La Spezia where we'll take a train to Vernazza. After Cinque Terre, we go to Florence for 3 nights stopping at Pisa along the way. Then, back to Venice stopping for 1 night in Bologna and Comacchio.
No specific reason for Bologna. Comacchio was recommended by my Italian partner as an interesting town with a specialty in eel. Looking for places to break up the drive.
I'm also wondering if 2 nights in Venice is sufficient. We've never been there before. Maybe we should have planned a longer trip :-)
My Italian partner also recommended Lake Garda as a nice place to spend time and visit wine area in Franciacorta.
For Cinque Terre, we're staying 3 nights and contemplating a 4th night so spend time hiking and spending time in all 4 villages. Vernazza will be our home base while in the area as we hike and use the train to move to the other villages.
I've made most of our hotel reservations and made them all refundable so that I can adjust later.