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Travel from Italy to Switzerland

We have scheduled a repositioning cruise from Florida arriving in Rome in April (2015). We plan to spend about 3 weeks in Italy. Potential itinerary Rome, Florence, sienna, possibly a side trip to Volterra, then Venice. Here is the question. We have checked air fares to return to Fl ( Sanford Orlando airport or in proximity to Daytona) and by far much less expensive from Zurich. Has anyone made this trip? Any suggestions regarding Zurich?

Thanks.

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What airline? Venice to Zurich is pretty straight forward. One train change in Milan, about 7 to 8 hours.