It is finally happening: our dream trip to Italy is coming up in mid-September! This will be our first time in Italy and we are focused on Rome and Florence for the art, architecture, history and food. We'll be flying in and out of FCO from Miami. I've booked an apartment on the Campo de Fiori (Boutique Hotel Campo de Fiori) with the idea that we would spend the majority of our time immersed in Rome but scoot up to Florence by train for a couple of nights near the mid-point of our stay, then return to our Rome apartment to finish the trip which will coincide with our 19th wedding anniversary. So: 9-10 nights in and around Rome and 2-3 in Florence ... any thoughts, recommendations, cautions for a couple of novices such as ourselves?
EDIT: Yes, for the sake of convenience we plan to keep our apartment in Rome the whole time even though we'll be in Florence for a couple of days. Under normal circumstance we wouldn't spend that kind of money but this is a splurge trip. For us it's worth it not to have to check in/out and we look forward to not having to lug all our stuff to and from Florence ... we can take only what we need for a short stay. My rationale for going to Florence mid-way through our trip rather than starting or ending there is so we can do our train travel on a Monday, when I understand most museums are closed. Thanks for the tips so far and please keep them coming! :)