In 2012 we did the My Way Italy tour. Our first city was Venice and the first hotel was Hotel Serenissima. It took us over an hour to find the hotel from the boat stop and fortunately we ran into another couple with the same page of directions looking for the hotel too. Once we got there we were on the 3rd floor which is of course on the 4th level. No elevator. Very small room, shower smaller than a phone booth, no AC. Room was somewhat dirty.
Fast forward to September of 2022 and we just completed the Best of Europe in 21 Days tour. This included Venice and...you guessed it, we returned to Hotel Serenissima. On the 2nd floor which is the 3rd level. They apparently had done some renovations as the bathroom had newer fixtures and the floor appeared to be new tile. Shower still small but better than last time. However, only 1 outlet which was for the TV and clear across the room from the bed. We both use CPAP machines and both need to plug them in. Fortunately I brought two extension cords for just such a situation. Room was not clean and smelled musty.
The location of this hotel is perfect for seeing Venice. I would not recommend it for comfort, cleanliness, or modern furniture such as the bed. The hotel staff were exceptionally friendly and helpful however.