Hotels in the Ostiense are in Rome

You might also consider looking slightly outside the usual hotel options, depending on your travel style. Ostiense is well connected, so some people choose to stay a bit outside the city in quieter areas and commute in. If you’re open to more flexible travel, alternatives like small guesthouses, agriturismos, or even camping setups (some people travel with rooftop tents in Italy) can be a nice way to mix city visits with a bit more space and nature. That said, for a Rome city stay, most people still prefer something central for convenience. For Ostiense specifically, I’d focus on places close to public transport (metro/train), as that will make getting around much easier.