We stayed for one night at Hotel Al Santo in Padua in July 2014. The RS guidebook recommends taking the tram from the train station to the Santo stop for the hotel, and we were glad we did--it would have been a long walk with our bags (longer than it looks on the map). (It's weird that the hotel recommends getting off at the Prato della Valle stop on their website--we found the Santo stop to be closer.) Tram tickets were easily obtained outside the train station in a little building, and the tram stop was just beyond the ticket booth. We walked a couple of blocks from the tram stop to the hotel.
The hotel is basically a block from the Basilica of St. Anthony. The hotel's glass front door is very narrow (tough to get through with my backpack on!). The woman at the front desk was very friendly and spoke great English. We were on the first floor and took the small elevator up the first time, but then used the stairs after that. Our ensuite, non-smoking room #106 was a reasonable size (not tiny, not huge) with two beds, a desk, a mini-fridge, a wardrobe/closet, two chairs, and a safe. The air-conditioning was amazing (best of our whole trip). The bathroom was very small/tight with the smallest shower we experienced on our trip. (If my father had been with us, he would not have fit.) The water was hot, though, with good pressure. They also don't provide traditional towels; the towels are waffle-weave (for the bath towels) and flour sack (for the hand towels), which probably take less energy to wash.
The included wifi worked very well. While the pillows were comfortable, the beds were very firm. The woman at the front desk provided us with a nice town map which we used to explore the town on foot. The breakfast was standard buffet, with cereal, fruit, yogurt, pastries, sliced meat, sliced cheese, juice, and coffee. They have indoor tables and a small outdoor breakfast area (where we sat). The ladies working in the breakfast room did not speak much English but were very friendly! We had the time, so after checking out, we walked from the hotel to the train station (which takes quite a while). The room was 87 euros + tax, so it was a nice rate for a nice room, but I would look for more comfortable beds (if available) and maybe a more central location if staying in Padua again.