Since your interest is primarily the West and seemingly the Southwest, can you fly in and out of Shannon instead ? Dublin to Cork is a LONG haul on a first day....or Dublin to the west coast and back really eats up two full days. Flying into Shannon you would be reasonably close to many alternatives and leave time for a stop or two on arrival and departure day.
Would definitely decide on two bases as one, two night hops will eat time and leave it all a blur. You can't see the west in 6 full days let alone all of Ireland. The great thing is if you pick out 2-3 must sees for you and plan a couple centralized stops there will be tons of other incredible stuff close at hand to choose from in your areas of interest. History, villages, chances to experience historic and modern Ireland and her amazing people are all nearby.
As an example we spent a full week in Ballinskellig - about as out of the way as you can get .... yet using that as a base we were able to have within a super easy drive...Portmagee and Skellig Michael, Ringforts, an old Abbey, castle ruins, famine homes, the Ring of Skellig, The Ring of Kerry, great restaurants in Waterville, standing stones, breathtaking scenery, pubs with trad music, Cliffs of Kerry (better than Moher), beaches, lots of shops and the great people in a Gaelic language preserve. We ran out of time before we ran out of things to do. Same could be said of Dingle or spots in Donegal.
You'll have an amazing time....would just urge major trimming on stops...that will exponentially expand your enjoyment......and try and fly in and out of Shannon.