I've been to each spot in Kilkenny, Wicklow and Glendalough. I've also been to the Boyne Valley and the Hill of Knowth, which is similar to Newgrange.
If choosing between the two, I'd go with Kilkenny, Wicklow and Glendalough. Let's walk through each. Kilkenny is the best preserved medieval town in Ireland (with Ennis in County Clare the second best). County Wicklow is beautiful. In 1999, I walked the 100-mile-long Wicklow Way (https://www.wicklowway.com/) for seven days, loving the hills and mountains and glacial trenches. You can walk for a couple hours on the trail starting in Glendalough. As for Glendalough itself, it's a stunning series of antiquities, some around a millennium old. St. Kevin's Kitchen, an ancient church, is the best. Early medieval Irish monks translated Plato, Aristotle and other ancient Greek and Roman authors: It's at Glendalough where some of that work occurred.
The Boyne is beautiful, too, but doesn't compare. However, the sight of a Victorian workhouse of the sort Charles Dickens wrote about the Muiredach's High Cross, an ancient Celtic high cross, were unforgettable, in addition to Knowth.
Go to the tourist information office in central Dublin. They'll have a ton of information on tours of both spots.