Two Day Drive from Munich to Dusseldorf

P.S. This is for July 11-13 by the way, so I need to act fast. Thanks!

Driving the Rhine sounds like a good idea. I would recommend driving along the river from Wiesbaden to Bonn, or if on the other side, Bingen to Bonn. They don't really have self-contained "wineries" like you might see in California, Italy or France. Rather, the vinters usually grow the grapes on private allotments outside of town, then they used shared facilities to press the grapes and age the wine. You can walk through the vineyards (it's all public-access land), but there isn't a specific winery to tour. You can find distributors that allow you to sampe the products, but these may or may not have a direct connection to the producer.

The driving is not that long, so your planned stops in both regions have more affect. Depending on how many stops you make along the Romantic Road (where the point is stopping to see towns, not just driving), then maybe Rothenburg will be the right timing for your overnight stay. But if you want to get to the Rhine in one day, then it's another 2.5-hour drive from Rothenburg to Bacharach.

Thank you both! So if I stayed in Rothenburg, I'd still have time to drive the Rhine and make it to Cologne that night? Any specifics sites or attractions to see along the way? Would you recommend driving this over taking a train from Munich to Dusseldorf? Thanks fo your suggestions!

Here is a great resource for figuring out driving times and directions: http://www.viamichelin.com. I do think they tend to underestimate times a little and, of course, make no allowances for the inevitable German Staus.