By car it would be just driving down Autobahn 9 (A9); easy driving close to Berlin but more stressy the more you come to South and cities. South of Hermsdorfer Kreuz the landscape along the route becomes more scenic.
Detour via A4 possible to visit Erfurt and Bamberg.
Main sights on the way:
+ If you are architecture fan Dessau is must-have for Bauhaus.
+ Erfurt is worth a stop, also some castles around. Close Weimar is known as ciulture destination.
+ Same for Bamberg with beautiful UNESCO world heritage old town (little detur from A9 via A70)
+ Bayreuth is also culture and Bavarian history destination.
More sights along the way you can find on this map by German Travel Board; choose different options on the left hand side.
All these destinations are available by ICE fast trains. Only advantages by car you would be more time flexible at the one or the other destination and that you can explore the landside.
If you drive by car follow all speed limits directly and accordingly to max. +10 km/h. A lot of speed controls.
I was driving the A9 and A70 end of last year every week to Bamberg.