Hello Kathy,
Like always, the posters on the RS Travel Forum have great information based upon their myriad of experiences. I know I have learned a great deal regarding the planning of my bucket list trip this summer and I know I have been torn between some of the choices that posters have presented as I have been reading posts for over a year now. I presume you may have done the same Kathy.
But when it comes to the "style of travel", if you will, the best advice I might offer is that you travel the way that works best for you. For my wife and I, we have made our travel decisions (limited though they may be) upon the type of travelers that we are to try to insure the best possible experience that we could have and, I believe, this has been the most beneficial advice we have gotten from this forum.
For example, we know that we love cities - museums, history, cultural centers, food, etc. - and we know we like to have a "base" to work from when we are in a new city. We like to be in the center of things and work our way "out" into surrounding neighborhoods - the longer we are in the same place the more comfortable we feel. If a city doesn't have enough for us to do, see, or experience for us to be there for three days we seriously have to consider whether or not we should be going there. For us, spending just a day or two in a city and then packing up and moving on just doesn't appeal to us. I guess you could say that the excitement of visiting multiple places creates more anxiety than perhaps it is worth. For us there's enough travel angst in traveling itself when the goal of travel is to relax somewhat and actually be on vacation. We envy those confident and adventurous travelers who can pack up and move but that's not us.
This is why our trip this summer starts in Oslo (6 nights), Berlin (6 nights), Frieburg/the Black Forest (3 nights), Nuremberg (2 nights) and a Danube river cruise (the room goes to the sites!). In Berlin we will be staying at the Melia on Friedrichstrasse and the Spree River - right in the middle of the city, right near the main train station, right next to Museum Island. The prices are comparable with the other hotels in the Mitte and might be a place you could consider.