Frankfurt to Vienna

Be careful! There are a number of Salzberg s, but the town I think you want is Salzburg (the SOM town), in Austria. If you misspell the name, you might not end up where you expect to.

Are you thinking of the Rhine and Mosel rivers as your wine region? They are popular, but take you in the opposite direction from Austria, adding a bit to travel time. Rick's Austria itinerary outline suggests that you can see Vienna, Hallstatt, and Salzburg in 7 days, but then it gets stretched if you add a stop along the Danube around Melk (also a wine region) and Mauthausen (concentration camp).

The German wine route is in Rheinland-Pfalz, well south of the Mosel and Mittelrhein. I think it makes a great excursion, but it's nowhere near Munich and in the opposite direction of Vienna. I know Germany's wine regions better than Austria, but there's probably some between Munich and Vienna.

Munich is not located in a noted wine producing region. The closest is probably Franconia to the north.

Yes, going from Frankfurt to Munich, you will pass through north Franconia. Wuerzburg is specifically a wine region where the local wine is Frankenwein.
The Austrian wine region is the outskirts of Vienna.

Thank you all for your help! There are so many wonderful things to see and I think I'm trying to squeeze too much into a short period of time. Hate to skip the Rhineland and Black Forest but that will just give us another reason to visit the area again. It looks like Wurzburg is about 1 1/2 hours from Frankfurt. After traveling from the states we try to keep our travel time upon arrival to under 2 1/2 hrs so this would work. Also prefer not to pick up a rental car in an unknown area right away as well - Keeps the getting lost and bickering to a minimum :) Hoping that it might be possible to line up someone to pick us up at the airport and take us to Wurzburg (our somewhere in that area) and we could get our first peek of the Romantic Road which I've read about. My husband loves wine so I always try to find a guide that can take us on a fun winery tour that we might not otherwise be able to see. All suggestions greatly appreciated. Next thought is to leave there and head toward Munich (approx. 3 hours?) with a stop to see Rothenburg ob der Tauber. (Sounds touristy but too beautiful to skip. Hoping it won't be crazy crowded the end of April) After some time in Munich head to Salzburg stopping to explore Schloss Neuschwanstein. Should we try to go to Garmisch-Partenkirchen or is that just too much driving? Still working on the Salzburg to Vienna portion. Don't want to travel every day and would prefer a maximum or 4 different hotels. I'm I clueless?

Is there any reason for not using the excellent German train system? Station right there at Frankfurt airport where you can get a train that will whisk you quickly direct to Wuerzburg. A direct train nearly every half hour. Wuerzburg to Rothenburg is easy by train, and on and on all the way to Vienna. Travel on Bavaria is cheap with a Bayern Ticket.

Thanks to your help we are fine tuning the trip and are going to try to do it by train vs car. Start with a train from Frankfurt to Wurzburg. Hotel suggestions? would like to get out into the surrounding wine area but read that we would need a car to do that. We were thinking to then head to Salzburg - Hallstatt - Danube Valley area - Vienna. We have had several friends encourage going to the Lake Constanz area and stay in Lindau. This intrigues us because we had seen a lot of amazing pictures of Mainau (the flower island?) and I think our timing is perfect for the flowers. Would a ferry take us there from Lindau or would we need to stay in Konstanz? If we did this it would probably eliminate Hallstatt due to time. Wurzburg - Lindau - Salzburg -Danube Valley - Vienna.

Thoughts?