In addition to things like travel docs, my carry on includes a small bottle with a few of my likely OTC meds (Tums, aspirin, and the like as well as one or two chewable Pepto Bismols). Headphones--with a cord, not bluetooth--and phone/charger/powerbank are important. I make sure to update my Kindle Unlimited and have my reading glasses. Oh, and two pens for filling out forms and a moleskine or small journal. Gum and two snacks--one sweet, one salty--as well as a Nalgene I fill at the airport after going through security. For snacks, I like things you can eat slowly / in pieces such as M&Ms and Cheezits. Tissues and a few disinfecting wipes are also important. A small travel kit of toothbrush / paste, mouthwash, deodorant, hand sanitiser, lotion, a toothpick, and lip balm as well as clean socks, underwear, t-shirt (I prefer a workout type) and some lightweight shorts are also part of my kit. I carry a workout band for stretching, but that is completely a "me" thing.
Neck pillows--see if you can borrow some of varying consistency to find what works best for you, but don't travel without one. I don't use ear plugs or masks, but a lot of people I know do. Personal preference, weigh nothing. Some people swear by noise cancelling headphones. Regardless, make sure your headphones, whether ear buds or the bigger ones, are comfortable.
I find being well rested the day of departure and hydrating aggressively to be super helpful. Constant, small drinks--6 fl oz or so every hour--for two days before, eating as healthy as I can in that time, getting proper rest--these help your system handle the flight and the jet lag. I try to do some gentle and stretching yoga in those days even if I don't normally, and I try to go for a workout the morning of my flight.
Dressing carefully matters. Jeans are fine if they aren't super tight or restrictive. Otherwise loose clothing is preferred all around, as are layers as the plane can get a bit chilly. Again, being rested and hydrated helps, but so do layers--long-sleeved t-shirt and a sweatshirt are my summer go-to for that trip (I have done MCO-Europe/Germany often enough). But the key is footwear. You ABSOLUTELY should wear comfortable socks and shoes--no heels, nothing tight. Talk to your healthcare providers about compression socks. Consider that if you are connecting (we always are), you might need to run or move quickly. For me, it's always comfortable walking shoes that are relatively easy to remove/put on. I take them off once we have ascended and generally only put them on to go to the bathroom or as we descend. Socks are key here--I cannot understand the people who walk around the plane barefoot.
We like to leave for the airport early--being there two hours before is a minimum and has been since long before it became a requirement. Online check in and selecting good seats (we often pay for the Economy Plus upgrade) help. Check in, go through security, and find your gate. Fill your water bottle, use the toilet, and pick up any last-minute items such as snacks you may have forgotten to get. Try to use the time to relax, but also to stretch and move. Don't eat at the airport if you can avoid it or stick to salads.
Once settled in your seat, try to go straight into the zone. You'll get your meal, and they will dim the lights. Try to go for a quick bathroom break and walk/stretch after the meal. If you can, try to sleep. This is where a book is better than movies, but if you are like me and can't sleep, movies work. I find watching the same stupid movie twice helps. Dumb SciFi like The Meg work well for me--no need to concentrate on the plot or feel badly if you do fall asleep and miss the ending. If you are awake mid-flight, walk and stretch, but pay attention to your surroundings so you don't have issues with a flight attendant with a beverage cart or another passenger headed to the bathrooms.
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