Fall visit to Rhine & Mosel Valley

My husband & I are adding an extra week onto an upcoming September business trip and looking for itinerary & accommodation advise to explore 3-4 days in the Rhine/Mosel area - specifically for the hospitality, scenery & lovely wines. We'll fly into Brussels, renting a car, than staying 1 or 2-nights in Bruge. Than after quick stop in Koln to see cathedral we'll be on our way to either the Rhine, Mosel Valley or a central location between them for 3-4 nights before we're off to Heidelberg for business. We would very much appreciate any recommendations to simplify, see the highlights and make the most of our short time in this beautiful area. I should mention we've travelled all over Europe using Rick Steve's guidebooks and have always been thrilled with his recommendations!