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Driving from Frankfurt to Lake Constance

Outside of the Strasbourg and Colmar region, where we know what we want to do. Can anyone please give some potential highlights (scenic and historical) of a drive between Frankfurt and the Lake Constance region. We have about a week for this. Thanks in advance.

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See my response under this thread on driving from the Mittelrhein to Füssen/Garmisch-Partenkirchen. The routes are basically the same until you hit Memmingen.

You could also consider driving via Stuttgart south on A81. Other than Burg Hohenzollern at Hechingen, Tübingen and maybe a far detour to Sigmaringen, I previously found driving this route surprisingly dull.