Can anyone recommend a driver or company for transportation from Nuremberg to Prague for 2 people?
You can try this platform to find / book one: https://www.mydriver.com
Buses from Flixbus and Regiojet are much cheaper.
You can use Omio for price comparisons.
An overview over the bus operators (Regio Jet, DB, Flixbus, Eurolines...) can be found at www.busliniensuche.de. A well known transfer service is ckshuttle.cz.
Deutsche Bahn books bus tickets from the Nuremberg Train station to the Prague main station. Bahn.de
For the Nürnberg to Prague IC bus, www.dbicbus.com/?s=5471014&z=8089291&lang=en.
For Bahn schedules, use this link. Bahn.de gets you here eventually; why not start here?