It has been many years since I have flown Lufthansa, but it was a good airline 40 years ago.
We live in South Georgia and mostly fly on Delta/KLM/Air France. Delta in my opinion is the best US airline. United is second and American third.
Air France is fantastic and prefer it when connecting in Europe.
TAP was nothing to brag about, and Iberia was one to avoid.
I hear from friends to avoid Air Italia.
I have heard positive things about Turkish Airlines.
We did a Safari last year in Kenya and Tanzania and flew to Amsterdam on Delta, then used Qatar Airways to and from East Africa. We had one long layover in Doha, which involved getting a hotel for several hours. The flights were generally OK, the food was actually pretty good. However, on two of our four flights either mine or my wife's screen to watch movies didn't work and nothing was done to fix it. I think they just didn't function. Also, on our last flight, I was moved from my aisle seat (already had the boarding pass for it) when I checked in (with no explanation). I politely asked why I was moved to a middle seat and the attendants were very rude, saying you don't own the seat, we have the right to move you. We will never fly again on Qatar, despite their low rates.
Egypt Air, we took because it was included on a tour of Egypt. We flew from JFK to Cairo. It is the only airline that flies directly from the USA to Cairo. The flight to Cairo was 17 hours late leaving and we were told by someone in the know that Egypt Air does this every six months or so when their airplanes need servicing in NYC. Because of that we had to stay a night in NYC and the reimbursement for the cost was not enough. Also, while on the flights many times getting an attendant was very slow or impossible.
Don't fly Egypt Air.
We have flow on Korean Air Lines and it was great. The food, service and comfort was super.
I always use Kayak.com to check for flights and then book directly with the airline. Usually Delta is our pick, unless we can save. Usually Delta, United and American are about the same.
Also, I have heard positive things about Icelandiair.