"While we realize the trains are efficient, we want to limit our hauling of luggage in and out of stations etc to the beginning and end of our trips."
These days I travel exclusively by train in Germany. I'm not bothered by my luggage at all, and I credit Rick Steves and his very intelligent packing advice for this. DW packs as Rick advises as well. On recent trips she has experienced certain age-related mobility issues (we're both 70.) When boarding/deboarding some trains and buses, or when transiting between tracks (think stairs,) she needs both hands mostly free for safety. But it's not an issue for me to handle both our bags - as long as they are "Rick-packed" - for these brief moments. Otherwise, we each handle our own bag. We move a little more slowly both in stations and outside stations than we used to, but that's just how we are. It's got nothing to do with our luggage. It's the long walks in certain AIRPORTS that might bother us, but rail stations tend to be a snap by comparison.
So I tend to look at train stations as a travel BLESSING rather than a curse. I never have to search for or pay for parking. And when it's raining, I am not fumbling around with my umbrella in an attempt to stay dry as I leave the front seat, open the car trunk, and pull out my luggage with my third hand... and I'm not immediately running for shelter. I just step onto a dry platform, bag in hand, and then into a mostly warm/dry station lobby (where a hot cup of coffee often awaits me.)
Some additional logistical planning is helpful with trains as well... especially if you refuse Rick's packing strategies...
1.) Stay fairly near the station so that you don't have to walk for 20-30 minutes or more to your room or take a local bus.
2.) Use "hub and spoke" planning, like you are doing in Boppard, in other places. For example... make either Würzburg or Nuremberg the hub, and day trip to the other and to Rothenburg.
3.) Select hub destinations that can be reached with fewer changes of train. It's 1 train to a Salzburg hub from Munich, but 2 trains if Berchtesgaden is your hub.
4.) Don't duplicate experiences that cause additional journeys with luggage. Why go all the way to the Alps in Füssen, then to other Alps in Berchtesdaden, for example? Pick one alpine destination or the other, and stay a little longer.
5.) Turn a hub into a spoke. If you're staying in Munich at the end, don't make expensive Salzburg a hub; instead, add a night or 2 to Munich. Then do direct a day trip from there to Salzburg (1.75 hrs by direct train) and to Füssen or Mittenwald. I would do the Salzburg day trip on Sat or Sun (travel at any hour on the Bayern Ticket) and plan on a long day as there's lots to see in Salzburg.