Hello:
We (4 adults) will be making our first trip to Berlin and Prague in August 2019.
My wife and I visited Bavaria and Salzburg this past August and we had a wonderful time.
https://community.ricksteves.com/travel-forum/germany/munich-salzburg-bavaria-itenerary
My aim during planning is to base at each location for 4 nights to give ourselves flexibility to shift things around during our time at each base if necessary. Here's what I have planned, love to hear some feedbacks.
Day 1 - Arrival in Berlin (4 nts)
Day 2 - Berlin
Day 3 - Berlin
Day 4 - Berlin
Day 5 - Pick up rental car and drive to Potsdam for the morning, after lunch drive towards Leipzig with a stop at Wittenberg, sleeps in Leipzig (4 nts)
Day 6 - Day trip to Quedlinburg
Day 7 - Day trip to Erfurt and Wartburg Castle
Day 8 - Return rental car and see the rest of Leipzig
Day 9 - Take DB Bus from Leipzig Hbf to Prague, sleeps in Prague (4 nts)
Day 10 - Prague
Day 11 - Prague
Day 12 - Prague
Day 13 - Český Krumlov (2 nts)
Day 14 - Český Krumlov
Day 15 - Flight home from Prague airport