Anyone have experience with these two hotels in Munich?

I didn't stay in either of the two hotels. But although the two hotels are close to each other, I would prefer the 25 hours in terms of location.
The 25 hours is in a historic building directly opposite the main train station. Well, the main station is a huge construction site right now, but right next to the hotel is an escalator to the mezzanine of the main station and Schuetzen-street leads directly to Karlsplatz and the pedestrian zones in the city center.
Schiller5 is in Schiller-Strasse which is a bit shabby and the building next door and the building on the other side of the street are currently under construction.

I have been to the restaurant (Neni) and the bar of the 25 hours hotel, both are very stylish and the food at Neni was really good. But you could also go there if you stay at Schiller5.

Don't worry too much. Neither hotel is bad and the impact of this decision on your trip will be minimal.

Also heard near the main station, is not safe? True or false?

I agree with everything Mignon has said. I suggest you look for a place up around the two art museums and the university. If you are close to an underground (U Bahn) it's very easy to get into the old part of the city, and I like that part of town. The alternate would be to go south of the river, but while that's also a nice neighborhood I prefer to walk along the English Garden in the evenings.

Rather than being near the main train station you may wish to look for hotels near Marienplatz which is a lovely area and also near S Bahn stops. We liked Hotel Torbrau, but there are many other hotels in that area which may be less expensive. Look at Trip Advisor or Booking.com or Hotels.com and you may find something that you like better than your original choices.

I stayed at a hotel near the Munich HBF last September for two nights. I will agree that all the construction at the station makes that area look pretty unattractive, though I never felt unsafe. I've visited Munich a couple of times and stayed closer to Marienplatz, so seeing this part of Munich was a little bit of a surprise. I can second the recommendation, above, for the Hotel Torbrau.

I agree with the previous posts - I found the area near the train station not to be comfortable. I stayed at Hotel Torbau as well - it was across the street from a subway station and at one of the old city gates. It was very walkable to all the sites, restaurants, grocery stores, shopping, and an easy hop onto the subway.

Hi all- just to close the loop on my original post. We stayed at the 25hours hotel. The location is fantastic if you are going to be using the trains for day trips etc. Yes, the area is under construction and is not pretty. Glad we picked the 25 hours as the other hotel was more in a construction zone. While not a pretty part of town, we felt completely safe and the walk to marienplatz was 10 minutes. Wr never had any issues (2 girls..:evening late at night). It would have been great if we could have stayed in the old centre but they were either sold out or extremely expensive during Xmas markets.

Like I said, the convenience of having the train station and all the underground shops across the street was great.

Hope that helps.

25hours is new to me. Any idea what the 25hours refers to?

Times have changed, we lived in Augsburg, 50 miles west of Munich. From 1987 -1991, we found Germany to be very safe, with little danger of being attacked, mugged, etc.

We have a German friend that married an American and lives in our area in the USA and I see her occasionally in the community. She goes home every year to visit her family and says that things have changed for the worse regarding crime. She says that now she doesn't go out at night in areas that she once did so with no fear.

All great responses. Very candid which is appreciated. Still looking.