Wilde Aparthotels Berlin: Checkpoint Charlie area or Adina Apartment Hotel near main train station

I haven't stayed at either but I did like the Adina at Hackescher Markt, which I also thought was very well located for sightseeing, food, and local transportation.

I suggest you look at Google Maps to see how convenient the hotels you mentioned might be to the sights you want to see, and what eating options are nearby.

I've stayed at that Adina Aparthotel. I found the hotel to be extremely convenient for location and amenities. I booked a one-bedroom in order to be assured of having a washer and dryer. I requested a courtyard unit at checkin, which was very quiet. The hotel is a 10-minute walk or one tram stop away from the Hauptbahnhof, which is a transportation hub for Berlin. One stop in the opposite direction is a shopping street with a convenient supermarket for snacks, drinks, etc. The only issue I had was with the internet, but my stay was several years ago and I imagine the problem is now solved. The breakfast was very good at the Adina. I've found that chain to be very reliable in Germany and really liked the Nuremberg location.