My wife and I are experienced travellers in France and have been here for a few days. I thought that I would provide an update on the strike and its effect on travellers.
This strike has already cost us about $500 extra in rental car costs, fuel and tolls.
My advice - if you have a low tolerance for hassles, and your trip to France involves multiple destinations then change your plans. Stick to one city, travel by train on the weekends (maybe), rent a car or go to another country.
At first the rail staff were on strike on Tuesdays and Thursdays. But, some Eurostar and other international trains were running. This is now changing by the hour.
Today (Wednesday) the train workers are on strike in Toulouse. SNCF shows only one train from Toulouse to Carcassonne for Thursday (the data changes frequently). The SNCF site does a good job of showing which trains will not run, for the TGV, enter your train number to see the status. Searching by time will not work.
Also, the truckers who deliver fuel went on strike earlier this week causing long lines and much aggravation at the pumps. The best place to buy fuel is on the highways. We are not certain of the status of this strike - it seems to come and go.
If I were planning a trip I would rent a car from Enterprise/National or Europcar. The car rental is surprisingly inexpensive, but the tolls and fuel prices are huge. I drove from Paris to Nimes and fed at least 60 Euros into the toll machines.
Critical info - download the Waze app. Everyone in France uses this on the highways. The French dispense speeding tickets automatically. People here use Waze to report on which areas have active monitors.
Final thought - with the strike going on this is a perfect opportunity to get in a car and visit small towns and villages. This is what we did on this trip visiting Nimes, Orange, St. Remy and about 10 others in the Luberon and Provence.