We will be spending 3 nights in the Burgundy/Beaune area driving there from the Loire valley. Afterwards we'll head up to the Alsace region where we'll be spending another 3 nights before dropping our rental car in Strasbourg and catching a train to Paris and then home. I have several places booked and I have to decide where I want to stay so I can cancel the other two places. I have a B & B booked in Beaune, one in Aloxe-Corton and one in Puligny-Montrachet. I can't decide where to stay, a smaller village or Beaune, where we can walk to places to eat in the evening. We will have a car.
Since you have a car and these are short drives from each other, I do not think it matters very much. Beaune is the livelier place, but you can get there easily if your other B&Bs seem especially attractive.
One thing in favor of Beaune, maybe, is that you can rent bicycles there, which is a wonderful way to visit the surrounding towns.
Don't miss the tasting lunch in Aloxe-Corton.
By the way, traveling from Burgundy to the Loire and then to Alsace is a lot of doubling back. Is it possible for you to enjoy a more efficient itinerary? Burgundy in the middle would do it.
Adam, Sue is driving from the Loire to Burgundy to Alsace.
Sue, I'm not familiar with the two small towns you named so I'm no help but wanted to say we really liked Beaune.
I did a tasting at the Chateau Aloxe-Corton, seems a pleasant village. Puligny-Montrachet is the home of some very expensive wine.
Beaune was my absolute favorite ( next to Pierrefonds) town to stay in.....with a car outlying villages are very doable and of course renting a bike (which we did) allows you to see the countryside and visit some wineries. We stayed in a B & B just outside Beaune's city walls and the owners were most gracious, welcoming and helpful. My one regret is that I didn't allow for a longer stay!
We stayed at the Carpe Diem guesthouse in Massangis not too far away. It was wonderful, the price was great, and the owners friendly and helpful. It is within a tiny town but accessible with car to many sights...we stayed four or five nights, driving all over, and never ran out of things to do. Highly recommend the Carpe Diem Guesthouse. I found it on tripadvisor.