So, there is a nonstop from AMS to DTW, so I assume you are saying that the # of miles
required for that flight is a lot more than the two ticket setup you discussed initially?
It seems kind of insane that two separate tickets is twice as many miles as the single
ticket AMS-CDG-DTW. It also seems insane that this is less than the nonstop AMS-DTW.
If you want to put your travel date in here, we can double check things, but I assume
you know what you're doing.
As far as your question about what Air France will do if you miss your connection
with a single ticket for both flights, there are rules involved here. First off, there
is duty of care, which means that if you have to spend the night, they have to
provide hotel and food vouchers. Second, if you somehow miss the transatlantic
flight due to delays, they have to get you on the next available flight, and in some cases,
provide compensation.
You should not have to go back through immigration if your flights are all on one ticket.
You may need to clear security again, but I don't know how CDG works to that level of detail.
Finally, mile redemption amounts do change, so even if you book now, it pays to keep checking
in case a better option makes itself available. But make sure you know the cancellation
T&C for using Flying Blue miles.