In defence (ha!) of La Défense, which is the main business area of Paris and full of office buildings, it is very animated and pleasant during the day, and it has La Grande Arche as a tourist attraction. In the evenings, it is probably very quiet; I have only been there during daytime, as I used to work there some years ago.
However, from a point of view of communication to central Paris, it is not inconvenient, as it is the start of metro Line 1, going straight to Etoile, Concorde, Louvre, etc. It is also a station on RER A, the one going to Disneyland. The Renaissance Hotel is at the back of the Grande Arche, and the metro/RER station is in front of the Arche.
Of course, it is nowhere near the image of Paris that most tourists are looking for.
Up to you to decide!