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Provence in late March - suggestions requested - 5 nights

Hi - a few questions after reading Rick's recent book on Provence for our group. 3-4 couples, trip focus on wine/food with a little bit of history, scenery and bicycle rides. It's the first 5 days of a trip that will end in Brussels to meet friends and watch a bike race. We will rent cars, so thinking home base of Vaison-la-Romaine, with a possible switch to Rousillon. Will everything be open the last week of March? Have concerns things don't open until Easter, which is quite late next year.

Saturday - get there, find decent meal
Sunday - history, walk town and a nice long meal to flush out jet lag
Monday - AM visit site, afternoon winery & nice meal
Tuesday - market day then to Roussillon?
Wednesday - bike ride to Gigondas (if no Roussillon) or bike ride in Luberon - wine/food built into trip
Thursday AM - back to Avignon to catch TGV to Paris/Brussels

Let me know if basing in Vaison-la-Romaine makes sense (only area of France we're visiting this trip) and any wineries/restaurants/hotels to recommend above most recent book. This is a celebratory trip so expensive hotels/meals will be okay.

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We were there last April and broke up our stay into two places. Stayed at Hotel Henri in Isle sur la Sorgue which is a beautiful town with water wheels and markets. From here we traveled to Roussillon and Gordes. Then stayed in St Remy, another beautiful town and visited Le Baux and Arles from there. Arles had a fantastic market which was over a mile long. Also really cool historical sites. In St Remy we stayed at Villa Glanum which is a short walk into town.