Some general thoughts:
If you don’t have experience doing hand wash while traveling let me know and I'll let you in on a few tricks.
Do not take a hair dryer. Every place we’ve stayed in the past eight or nine years has had one in the room. Or one can borrow a dryer from the front desk. Worst case scenario buy an el cheapo there.
Take only black, white, and grey clothing that can be mixed and matched. A splash of color can be added with a scarf or tee or tank. Take things that are light weight, wrinkle free, and will dry quickly. Several sources are Magellan's, Travel Smith, and Chico's. All have web sites and Chico's has regular stores.
For medications, get an extra label from the druggist, put it on a freezer zip lock, put the meds in the baggie. Saves space and weight. Just take the data sheet with you to show what it is and that it is for you.
Take very little jewelry. One or two necklaces and ear pieces at the most.
Take only two purses at the most. Her regular day bag will do ok for daytime. If she you feels the need for another then a small clutch for evening.
Do not take a lap top or tablet. Just takes up space and adds weight. Email can be checked with a smart phone at a Wi-Fi hot spot.
No matter if checking bags or only using carry on bags (or both) always put half of her stuff is his bag(s) and half of his stuff in her bag(s). Checked bags do get "lost" and carry on bags are sometimes gate checked no matter what the size / weight. If one of the bags goes on its own vacation, you will still be able to get by.
Clothing for Her:
Three under shirts – two regular and one tank top – wear one and pack two.
Five underwear -- wear one and pack four.
Three bras -- wear one and pack two.
Five pairs of socks – wear one and pack four.
Two pairs of shoes – wear one and pack one.
Three pairs of pants – wear one and pack two.
Three shirts or blouses – wear one and pack two
One jacket and one belt – both to be worn in route.
One vest (optional), one sun hat, and one light sweater – all to be packed.
Rain coat to be packed.
Do you also need a packing list?