Itinerary advice by region/day

D'Orsay and Napoleon's tomb can be grouped together. It is a 10-15 min walk from one to the other. Shakespeare and Co. is just across the river from Notre Dame, a 2 minute walk. St Chapelle is walking distance from Notre Dame. There is a security line at St Chapelle, D"Orsay, and Louvre. It may take a while to enter, depending on how long the line is. Sacre Coeur and Montmartre deserve their own half day. Eiffel Tower and river cruise could be combined; I think some of the boats leave from there. Batobus is one of the boats that makes the rounds up and down the river in the central Paris area. Eiffel Tower, D'Orsay and Notre Dame are stops for Batobus. You will be staying in the neighborhood of the old opera house, so you can see that when it is convenient (maybe in the evening?). Pere Lachaise deserves its own half day. To enjoy it, expect to walk a lot and pause often. I hope you have a Rick Steves book on Paris. There are walks and details there. If your wife tires easily, take an occasional taxi. It helps a lot not to have to climb stairs and deal with the Metro all the time.

Perhaps get a map of Paris, like the one in the back of the RS Paris guidebook, and mark the sights you want to see. This will help you group them geographically, and make daily planning easier. The guidebook will tell you which days each site is closed or very busy, so you can avoid them.

By the way, it's Sacre Coeur. What is ET? ( oops never mind- figured out its Eiffel Tower)

As mentioned previously, Shakespeare &Co is just a block or 2 from Notre Dame, on the Left Bank. It has a coffee shop next door, if you need a break. Our favorite lunch place is right across the bridge from ND, on the Left Bank. It's called Cafe Panis. Touristy, yes. But the food is decent and at a decent price. Plus it has a view of ND! If you need a break after the Cathedral and Ste Chapelle, I can think of no better place.

Great tips! Sorry for the misspell. That was an autocorrect. ET is Eiffel Tower.
I love the restaurant idea and will add it to the plan. Thx so much! What do tou like to order there?

Our first day - we took the "Big Bus" one of many hop-on hop-off buses - we boarded at Notre Dame and rode the whole route......just to get oriented where things were and then the next several days - we went to the places that we wanted to see.
We were staying in Marais area and used the metro a lot to get around.
(we had purchased a 1 week museum/transportation pass.)
It was perfect for us. PS the big bus had a map of the city that they handed out and that helped us figure out where we were and what we wanted to se.

Good tip! Do you remember how long the tour lasted?

The HoHo buses can take as long as you want, if you want to wander around. Check OpenTour or Foxcity for length of tour and stops.

I believe the Batobus stops service in the wintertime. Anyway, it's very crowded and slow, and in many cases there are long flights of stairs down to the dock.

Be prepared for crowds.

Asian tour groups are expected to increase by 60% this year. Australians and Americans make up the rest.

Buy advance tickets for the Catacombes, but if your wife has trouble going down lots of winding steps, I might skip it.

Get a Museum Pass if it makes sense to you monetarily. There will be a dedicated Pass Holder's entrance, but you have to pass through Security.

You can go to the Louvre and the d'Orsay the same day, if you just want to hit the highlights. But the Louvre is enormous, so do some research on the official website to see where things are.

Notre Dame, Shakespeare, and Sainte-Chapelle can be done in one day. Book advance tickets for the nighttime concert.

Eiffel Tower, Les Invalides (Napoleon's tomb) and Opéra Garnier - as long as you're going back to the hotel - also do-able.
Might reverse the order and take the night river cruise to see the monuments, bridges and the Eiffel Tower in one fell swoop.
Check sunset times before booking online tickets. Bateaux Parisiennes docks near the Eiffel Tower.

Might be a stretch to make Sacré Coeur if your wife can't handle hills or steps.

Père Lachaise is easily reached by bus or Metro, but is truly enormous.

If you need a taxi, go to the nearest busy intersection and look for the green light on top. Good idea to print out the address of your hotel - including the Postal Code.

We stayed at the Marriott Opera last fall. Do use the metro to get to the core sights near the river as well as ET and Napoleon's tomb. Even Montmartre. It's so easy and will save your wife's energy. You will still have plenty of walking to enjoy the city. Group your sights geographically with an eye on closed days and late open hours.