I have done a similar trip more than once, arrive CDG late morning and take the TGV to the south of France. Four hours is plenty of time, I give myself 3.hours. Presuming your flight is on time the time will allow you to take a breath and REGROUP before getting on the TGV. One of the first things I do is get euros from the ATM machine. Then I can sit and savor a cafe au lait. The maps are okay for directing you in the terminal to the TGV station. Then I walk to the TGV area, If I remember correctly, there is a snack place and restaurant nearby. A place to watch other travelers and begin to accustom your ear to hearing French.
The first time I did this trip, I studied carefully the online maps of the airport. CDG can become crowded with travelers moving quickly, think BWI or Atlanta. By spending the time learning the layout, identifying where the ATM machines are, and the TGV location and the route through the airport to it helped me feel in control even though I was exhausted. If I remember correctly, its been 5 years, you need to go down one or two floors to get to the TGV counter and platforms. The maps clearly indicate its location. Also the airport website gives helpful information.
As this is your first time to CDG you may want to identify the arrivals terminal your airline uses and write out the directions from arrival to TGV and keep them handy for when you clear customs. This will also help reduce panic if your 4 hours gets reduced to 1.5 because of delays.
I prefer to buy my TGV tickets before departing the US, (sncf.com) usually I can get first class tickets at a cost slightly more expensive then 2nd class. This is a treat for me, but after a long over nght flight (13 hours from west coast) a little pampering is in order. The first class compartments are usually quieter and allow me to get a few cat naps before I arrive at my destination in the southern part of the country.
Also, Before leaving CDG I break my euros into smaller coins/bills and put a few in an easily reached place to buy coffee on the train and pay for the bus or taxi at the other end.
Have fun, I will be doing this route to CDG to Arles in August , it's easy!
Julie