We are staying near Gare de Lyon and were planning to fly to Venice. It's cheaper and even with travel to and from airport after hotel check out, it's still only about 7 hours from door to door. It would involve several different modes of transport (stress) and flying (I hate flying).
Or we can take the TGV from Gare de Lyon (1/2 block walk) to Venice. One change in Milan. 10 hours on trains and one hour connection time. With travel from Marco Polo included, both arrive in Venice at about the same time. The only difference is having to leave the hotel if we fly at 10:00 versus leaving the hotel at 5:45 if we take the train.
That takes 4 hours of down time for a leisurely wake-up time and breakfast, but the train ride is much more relaxing and interesting, I think.
What would you do?