Driving hints for Alsace region

Read this. http://about-france.com/travel.htm
You did not say if you are renting the car locally or at an airport.
It would be a good idea to stop by AAA and get an International Drivers Permit. They don't cost much and could get you out of a jam if you get stopped and the cop has no idea what a (name a state or province) drivers license looks like. The IDP acts as an official translation of you license.
If you drive on toll roads (most super highways), have a supply of euros, preferably coins, to pay tolls. No special stickers needed that I am aware of. Technically, your rental car should include a safety vest, fluorescent break-down triangles, and the all-important personal breathalyzer kit.

If visiting Strasbourg,l don't drive in.

Park at one of the many park and rides and take the tram., or take the train from wherever you are.

Cheapest fuel at supermarkets, most expensive at named chains. At the moment - and this regularly changes - Swiss fuel is much more expensive (around CHF 1.49 per litre), German is in the middle, and French fuel is cheaper at around €1.07 or so.

The stickers you might need if you go further afield are the Vignette to drive on Swiss highways if you go a bit south, or the pollution sticker if you go into the centre of towns in Germany, just across the Rhine.

1. Get an IDP for each driver before you go. While you may never be asked for one, it's mandatory.
2. GPS is invaluable. The roads in Alsace are well-maintained but signage isn't great. Also, it can be difficult to find your way in the larger towns and cities.
3. In Colmar some parking lots have sections that are only for permit-holders. I didn't see that anywhere else. In most towns you usually have to pay for parking (in lots or on the street) by paying at a nearby machine for a specified amount of time and displaying the receipt on the dashboard.
4. Some historic centers may restrict traffic to local residents. Watch for the no-entry signs.
5. On the limited access roads, speeds are usually monitored and if you go over the limit (even by a little) you are likely to get an expensive ticket in the mail. I had no trouble paying tolls at the booth machines with bills, even €20's. There are rest stops on these highways with gas stations. The gas prices are significantly higher. Gas up before you get on them or wait till you get off them.
6. On the other roads, speed limits are not always posted. You are expected to know them. Maximum is usually 50 in towns and 80 outside them. Based on the number of drivers who passed me at higher speeds on these roads, most of them are not monitored. My guess is that locals know where and when they can speed.
7. The blood alcohol limit is low at 0.5% compared to the U.S. 0.8%.

We are picking the car up in Germany, and returning to Germany. That was partially why I wondered if any special stickers were needed in France, assuming the German based car may not have all the requirements. I was not aware of toll roads in the Alsace region. Thanks for all the helpful replies!

If there, they would be on the A-35, but viamichelin says no tolls on the stretch between Strasbourg and Colmar.

viaMichelin is right in this case.

The first tolls are just north of Strasbourg, and then that autoroute is tolled all the way to Reims.

Where in Germany and where do you intend to enter? There are interesting things about several of the crossings, and now that Germany is closing borders there could be queues.

Just checked, the tolls I paid were in Burgundy and then from there to the Alsace.

Not sure where we are crossing yet. We're actually picking up the car in Germany south of Munich, heading to Austria for 2 days, then back through Germany before driving to France. I'm assuming we will be hit with a number of delays due to passport checks. Hopefullly delays are all we encounter!

In Austria, you need a vignette/sticker on the windshield. It was easy to buy near the border.

The wine road west of Colmar is a nice drive linking small towns. We watched the grapes being harvested along the way and walked in many towns. Look for parking outside the walls of each town. The towns either have no cars or very few which I assume had special permits.

The country side got very dark, no street lights and no houses along the road, no light for miles. We were really glad to have gps driving back to Eguisheim after dinner.