Driving from Bayeux to Beaune

You can take their timings as an estimate - fine if nothing goes wrong, like accidents.

Maybe on a Sunday. Be ready to pay the tolls, and be very careful in the "average speed zones".

Give yourself an extra hour or two cushion...Google maps doesn't factor in times for gas/food/bathroom stops.

We drove this route numerous times when we were renting a house in Bourgogne near Beaune and looking for a house to buy near Bayeux.

Of course it's doable.

The fastest route involves a western pass around Paris; between Paris and Versailles. Keep in mind that A13 between Paris and Caen is one of the earlier highways in France operating under the flux libre (free flow) arrangement and that toll booths have been bypassed in favor of a remote billing system implemented by Sanef. I'm not sure how rental car companies are dealing with that, but as a general rule you have a short time to arrange payment online before fines begin climbing precipitously.

From Sanef's website:

After your journey on a free-flow motorway, you must pay your toll
within 72 hours. Beyond this deadline, non-payment of the toll is
considered as an offence and gives rise to a payment notice being
sent. * Payment within 15 days after the notice is sent: the flat-rate
penalty is reduced to €10, in addition to the toll charge to be paid.
* Payment within 15 days and 2 months after the notice is sent: the flat-rate penalty is increased to €90, in addition to the toll charge
to be paid. * Payment beyond 2 months after the notice is sent:
pursuant to the law, a category IV increased fine in the sum of €375
is applied by the Police Court. NB: penalties are triggered for each
journey on the free-flow motorway. For example, a late payment for a
return journey made on the same day will give rise to 2 separate
payment notices.