Paul I walked myself through literally the same process you're going through. Family of four, touch down 11:15 a.m. at CDG, want to go to Amboise.
We are seasoned at Europe travel with this being my 13th or 14th trip, and the 7th trip in the last 8 summers.
Trying to avoid going in to Paris and using the TVG station at CDG to go to Amboise is a massive time suck. You spend way too much time waiting around in stations for trains.
If we were going into Paris to transfer to Amboise, we would take a taxi to Gare Austerlitz and then TER Amboise. This would also put us in Amboise fairly late in the day.
So here's what we decided, family is pretty happy with it. We walk out of CDG to the taxi line and straight to the door of our hotel in the 9th. A taxi for 4 is basically the same cost as using public transit from CDG, and probably faster to our hotel. Likely arrival there between 1-2pm.
Drop the bags, wash faces, walk 10-15 minutes to Paris Opera House / Palais Garnier for a 40 minute gawk at one of Europe's supreme interior spaces. The massive Chagall modernist mural on the stately baroque hall's ceiling is in my opinion the greatest framing of any work of art on the planet. It's so beautiful I always wipe away a couple of tears. The reception hall there basically equals the fanciest rooms at Versailles. And the sculptures inside are priceless art nouveau masterworks.
Anyway, point is you can do one really cool Paris thing that you want to do, and it's easy if you get a hotel not too far from that thing.
Then back to the hotel to see if we can rally for dinner. If so, walk to somewhere on a sidewalk on the front side of Montmartre, walk up that hill after dinner if we feel okay, gaze upon the Eiffel Tower from a distance. Back to the hotel.
Or if we need beds badly just grab some sandwiches or take out and crash.
Next morning, we're a couple blocks in either direction from Subway lines that take us easily and directly to Gare Montparnasse, and from there an hour-ish to the Loire. As a bonus or subway ride is on a Saturday morning, not Friday at rush hour.
The pacing of our plan seems a lot more relaxed and enjoyable than grinding out the entire afternoon into the evening on the first day in convoluted train transit.
So that's just the way we decided to do it, I know a lot of people have different philosophies, prefer to grind out all the initial travel at once and be done with it.