The splendid citadel of Besancon, and the attractive town, have been in Rick Steves books. We did not have time for Le Corbusier's famous chapel in Ronchamp, but I would have liked to see it. If you are a modern art fan, I would mention the Fondation Beyeler, north side of Basel. Nearby Weil am Rhein, Germany, has the unusual Vitra Design campus and museum. Naturally you would have to tell your rental company about the countries you're going to drive into.
They are the "wrong way", but since you didn't provide your entire itinerary, I'd mention Perouges, and 3-star female-owned Restaurant Pic, in Valence.