Mike W,
Lots of forum commentators will recommend you don't try to drive far on arrival day due to tiredness, jet lag, etc. I agree that it can be a problem if you, like many of us, don't sleep well on the flight from the US. However, I do have some thoughts on your plan.
I suggest you check out drive times between locations. viamichelin.com is a good source for routes and times, but you need to add extra time for gas/food/comfort stops. When does your flight arrive in Paris? Is it overnight flight? Are you comfortable driving a few hours on your arrival day in a foreign country? Flight arrival times are when the plane lands, not when you are debarked. It may take only one hour or up to three hours to get to your car rental office, depending on how fast you get through immigration, etc. Our experience with picking up a car at CDG is that it takes at least an hour to get going (usually a wait in line, paperwork, finding the car and inspecting it, t familiarizing ourselves with the GPS, then exiting CDG (not fun!) and getting on the right road. By this time, jet lag may sink in. (I hope not!) Getting to Bayeux before the museum closes could be difficult depending on when your plane arrives at CDG.
Other than day one, it seems like a good plan, but please factor in your travel times between CDG and Bayeux, Bayeux and Amboise, Amboise and Tours and car return times.
Have a wonderful time in France.