Amboise as a base

That works.

We didn't self cater, but there are rentals there, as well as hotels. It's MUCH easier to explore the region if you have a car. We organized our explorations by area, visiting areas east of Tours on different days than those to the west.

I like Amboise as a hub, done it by train (harder), by car (easy) and by bicycle (much more fun). J

Self-catering there is nice -- especially if you time your visit to be there for the Sunday morning market !

I haven’t used Amboise but twice at Onzain - now known as Veuzain-sur-Loire. Worked out well

Donc, merci beaucoup mes amis. I appreciate your taking the time.
I am done. The end.